Noscab Cream

✔️ Uses of Noscab 5% Cream

Treatment of Pediculosis (head lice infestation) and scabies (skin infection)

✔️ How does Noscab Cream work?

Noscab Cream inactivates the nerve membrane and paralyzes the insects, eventually killing them. It can also kill the nits and eggs of the insect.

✔️ Side Effects: Noscab 5% Cream

Some individuals with scabies may experience mild skin discomfort, such as burning, stinging, or tingling after application. Other temporary symptoms can include redness, swelling, rash, itching, or eczema.

✔️ Quick Suggestions:

• Avoid sharing personal belongings such as combs, towels, scarves, and razors.
• Wash the bedding and clothes with soap and hot water after every use.
• Avoid scratching the skin as it may worsen the infection.
• Avoid direct skin-to-skin contact. Seek medical help if your sexual partner also develops scabies.

✔️ Indication of Noscab

Noscab is mostly used to treat parasitic infections. It targets eggs, lice, and mites. 

✔️ Pharmacology:

Permethrin, a pyrethroid, is the active ingredient in Noscab cream, which works as a topical treatment for scabies caused by Sarcoptes scabiei. It affects the nerve cell membrane of the parasites by disrupting sodium channel currents, leading to delayed repolarization and paralysis of the pests.

Pharmacokinetics:
Permethrin is only approved for topical use, and limited human data is available on its systemic exposure when applied to the skin. A small amount (less than 0.5%) of the applied dose is absorbed within the first 48 hours. Absorbed permethrin is rapidly metabolized, primarily in the liver, and its breakdown products are mostly excreted in the urine.

✔️ Dosage & Administration: Noscab

Dosage:
The recommended treatment duration is as follows:

• Adults and children over 12 years: full tube
• Children aged 6-12 years: up to ½ tube
• Children aged 1-5 years: up to ¼ tube
• Children aged 2 months to 1 year: up to ⅛ tube
• Children under 2 months: dosage not established

Use medication as per the advice of a registered physician.

Administration:
Before applying permethrin cream, ensure the skin is clean, cool, and dry. Avoid taking a hot shower or bath beforehand.

• For adults and children over 2 years: Apply the cream to the entire body from the neck down, rubbing it into the skin until absorbed. Ensure all areas are covered, including between the fingers, toes, under the nails, and on the soles of the feet.
• For babies under 2 years: Apply to the face, neck, ears, and scalp, avoiding the eyes and mouth.

Leave the cream on for at least 8 hours before washing it off. Reapply to any area that may have been washed during this time (e.g., after handwashing). If needed, repeat the treatment after 7 days as advised by the doctor.
Use medication as per the advice of a registered physician.

✔️ Interaction

Corticosteroids used to treat eczema-like reactions should be avoided before using Noscab, as they could worsen the scabies' infestation by lowering the immune response to the mites.

✔️ Contraindications

Permethrin is not recommended for those allergic to pyrethroids or any component of the cream. Healthcare workers who frequently apply permethrin may wear gloves to prevent skin irritation.

✔️ Pregnancy and lactation safety

In the absence of specific studies, permethrin should be used in pregnancy only under medical supervision. It is not known whether permethrin is passed through breast milk, so nursing mothers are advised not to use it.

✔️ Precautions & Warnings

Scabies are often associated with itching, swelling, and redness, which may temporarily worsen after starting treatment with Noscab. Patients should avoid getting the cream in their eyes, and if it does, rinse immediately with water.

✔️ Storage Conditions:

Store in a cool, dry place, away from light, and out of the reach of children.